新中医2006年5月第38卷第5期

神经生长因子穴位注射治疗感音神经性耳聋、耳鸣68例疗效观察

周枫; 吴萍; 王黎; 王海涛; 章少彬; 林薏; 钟慧; 陈燕华
（广州市耳鼻咽喉头颈外科医院; 广州中医药大学）

[摘 要] 目的:观察神经生长因子穴位注射治疗神经性耳聋、耳鸣的临床疗效。方法:将140例患者随机分为2组。治疗组 68例用鼠神经生长因子(恩经复)穴位(翳风、完骨)封闭治疗;对照72例给予西比灵、三磷酸腺苷口服及维生素B1、维生素B12肌肉注射治疗。结果:总有效率治疗组为78．6％,对照组为31．8％,2组比较,差异有显著性意义(P<0．05)。结论:神经生长因子穴位注射治疗神经性耳聋、耳鸣具有较好疗效,疗效与病程、年龄、听力损失程度成反比。

[关键词]：感音神经性耳聋; 神经生长因子; 穴位注射;

NEURAL REGENERATION RESEARCH　 Volume 2, Issue 9, September 2007
Efficacy of nerve growth factor on the treatment of optic nerve contusion

Aihong Miao1, Xiaoling Liu2, Shujuan Lü2（1Department of Ophthalmology, Tangshan Worker Hospital Affiliated to Hebei Medical University, Tangshan 063000, Hebei Province, China
2Electromyogram Room, Kailuan Hospital for Bureau of Mines, Tangshan 063000, Hebei Province, China）

[Abstract]　OBJECTIVE: To observe the effects of nerve growth factor (NGF) on PVEF in the treatment of optic nerve contusion, evaluate the clinical efficacy of NGF, and make an efficacy comparison with vitamin B12.METHODS: Conservative treatment was used in the two groups. In addition, patients in the NGF group were intramuscularly injected with NGF solution 18 μg /time, once a day. Those in the vitamin B12 group were injected by the same method with common vitamin B12 of 500 μg combined with vitamin B1 of 100 mg, once a day.RESULTS: Forty patients with optic nerve contusion participated in the final analysis. Before treatment, significant differences in the latency and amplitude at P100 were not found in patients between two groups (P > 0.05). For each patient in the NGF group, the latency of PVEP at P100 was significantly shortened, and the amplitude was significantly increased one and two weeks after treatment as compared with vitamin B12 group（t =2.06–2.34, P < 0.05）.
CONCLUSION: NGF treatment can obviously improve the visual function of patients with optic nerve
contusion. The curative effect of NGF is superior to vitamin B12.
[Key Words] nerve growth factors; optic nerve/injuries; contusions; evoked potentials, visual